Does Circadian Misalignment Have Sex-Specific Effects on Metabolism? (NCT07441265) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
United States36 participantsStarted 2026-10-01
Plain-language summary
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag). Researchers will examine how circadian misalignment affects appetite regulation (hunger/fullness) and glucose metabolism (blood sugar control), and whether these effects differ between females and males. Findings may help inform more personalized shift work schedules and targeted strategies to reduce metabolic health risks and sex-related differences in clinical care.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 18-40 years of age
* Body Mass Index 18.5-24.9 kg/m2
* Non-smokers, no current tobacco or e-cigarette use
* Healthy with no acute or chronic medical and psychiatric disorders
* Sex assigned at birth consistent with reproductive anatomy at enrollment (per protocol definition)
Exclusion Criteria:
* History of drug or alcohol dependency
* History of psychiatric illness or disorder
* Pregnant
* No prior gender-affirming hormone therapy and no gonadectomy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Difference in circulating leptin levels between Night Shift and Day Shift
Timeframe: 24 hours
2
Differences in Disposition index (DI) derived from identical test breakfast between Night Shift and Day Shift
Timeframe: 3 hours
3
Differences in self-rated cravings for hyperpalatable food during the wake period between Night Shift and Day Shift.