Timing of Subcostal TAPB Combined With Rectus Sheath Block for Postoperative Pain After Laparosco… (NCT07440940) | Clinical Trial Compass
RecruitingNot Applicable
Timing of Subcostal TAPB Combined With Rectus Sheath Block for Postoperative Pain After Laparoscopic Cholecystectomy
South Korea96 participantsStarted 2026-02-23
Plain-language summary
This prospective randomized controlled trial aims to evaluate whether the timing of ultrasound-guided subcostal transversus abdominis plane (TAP) block combined with rectus sheath block (RSB) affects postoperative pain in patients undergoing laparoscopic cholecystectomy.
Participants will be randomly assigned to receive the combined regional blocks either before surgical incision or after completion of surgery. The primary outcome is postoperative pain intensity measured using a numerical rating scale. Secondary outcomes include opioid consumption, incidence of postoperative nausea and vomiting, and other recovery parameters.
The results of this study may help optimize the timing of abdominal wall blocks to improve postoperative analgesia and recovery following laparoscopic cholecystectomy.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Elective laparoscopic cholecystectomy
* Adults aged 18 to 80 years
* Ability to understand the study procedures and provide informed consent
* American Society of Anesthesiologists (ASA) physical status I-III
Exclusion Criteria:
* Presence of significant pain unrelated to the target disease that may interfere with pain assessment
* Known allergy or contraindication to study medications (ropivacaine, acetaminophen, nefopam, or pethidine)
* Planned single-port laparoscopic cholecystectomy
* American Society of Anesthesiologists (ASA) physical status IV or higher
* Infection of the abdominal wall or skin at the injection site, or anatomical abnormalities of the abdominal wall
* Major neurological, psychiatric, or systemic diseases that may affect pain perception, treatment response, or study evaluation
* Requirement for postoperative mechanical ventilation
* Pregnancy or breastfeeding
* Considered unsuitable for the study by the investigator
* Refusal to participate or inability to provide informed consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Maximum postoperative pain intensity within 24 hours