Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Co… (NCT07438795) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study
150 participantsStarted 2026-06-23
Plain-language summary
Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and long-term pain persistence. This prospective cohort study aims to determine whether early post-amputation stump infection independently predicts persistent clinically significant residual limb pain at 3 and 6 months after surgery.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Traumatic upper or lower limb amputation
* Enrollment within 4 weeks after surgery
* Ability to provide informed consent
Exclusion Criteria:
* Pre-existing chronic pain in the affected limb
* Severe cognitive impairment
* Terminal illness limiting follow-up
* Refusal or inability to complete follow-up assessments
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is looking at whether stump infections after amputation lead to longer-lasting residual limb pain — based on my situation, does my doctor think I'm at higher risk of developing a stump infection, and would tracking that connection be useful for my care?
2Since this trial hasn't started recruiting yet, what's my doctor's best current understanding of what causes persistent residual limb pain after amputation, and how are they managing that risk for me right now while this research is still underway?
3This is listed as a prospective cohort study rather than a treatment trial, meaning it's observing outcomes rather than testing a new therapy — so would joining this study actually change any part of my treatment, or would it just involve monitoring and data collection?
4The study also tracks phantom limb pain alongside stump pain — can my doctor explain how those two types of post-amputation pain are different, and whether the infection-pain connection being studied here might be relevant to what I'm already experiencing or likely to experience?
5Are there any existing standard-of-care approaches to preventing stump infections that my doctor recommends I pursue now, regardless of whether this study opens to enrollment and I'm considered for it?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.