Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibul… (NCT07435883) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar
Egypt36 participantsStarted 2026-03
Plain-language summary
This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars. Thirty-six patients requiring root canal treatment will be included. The study aims to compare bacterial reduction and postoperative pain outcomes after treatment. Results may help improve irrigation protocols and patient comfort during endodontic therapy.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18-45 years with no sex predilection
* Medically free Patients with no systemic conditions that can affect post operative pain response.
* Patients should not be taking any pain medications 24 hours before intervention
* Positive patients' acceptance for participating in the study
* Patient able to sign informed consent
* Permanent mandibular molars diagnosis with pulpal necrosis with asymptomatic apical periodontitis.
* Mandibular molars without any anatomical variations or severe curvatures with mesial roots configuration weine class 3 and a distal root with 2 distal canals
Exclusion Criteria:
* Medically compromised patients
* Patients who have received antibiotic therapy within the last 2 weeks.
* Pregnant or lactating women.
* Patients with known allergy to any of the irrigants used.
* Patients with swelling or acute peri-apical abscess or fistulous tract.
* Teeth that have:
* Wide or open apex .
* Vital pulp tissue .
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
antibacterial effect
Timeframe: immediately after irrigation procedures