Not Yet RecruitingPhase 4

Examining Analgesic Synergy and Efficacy in Trauma Care

United States282 participantsStarted 2026-05

Plain-language summary

Traumatic injury is responsible for over 25 million (16%) Emergency Department visits and over 225,000 deaths each year per 2021 Center for Disease Control data. This is the 3rd leading cause of death in the US. Often, acute care for the injured patient requires administration of pain medication for the purposes of acute pain control from injury. The mainstay of treatment for pain control has historically involved opioid pain medication.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients with injury to at least 2 body locations as defined by Abbreviated Injury Scale (AIS) scores (Head, Face, Neck, Chest, Abdomen/Pelvis, Spine, Upper Extremity, Lower Extremity, External) Exclusion Criteria: * Glasgow Coma Scale (GCS) \<15 - Patients may be included if their GCS improves to 15 within 24 hours of admission * Age \<18 years * Age ≥80years * Prisoners * Pregnant patients * Non-English speakers * Inability to provide consent * Home buprenorphine or methadone use * Home opioid use \>45 Morphine Milligram Equivalents (MME)/day * Allergy to any medication within the study or control arm * Patients undergoing treatment for alcohol withdrawal * History of cirrhosis requiring dose adjustment of Tylenol

What they're measuring

The Numeric Rating Scale (NRS) Pain Scores

Timeframe: Day 14

Trial details

NCT IDNCT07435077

SponsorWake Forest University Health Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09

Contact for this trial

D'Ann B Hershel, MS

336-716-1659 Dann.Hershel@wfusm.edu

View on ClinicalTrials.gov More Opioid Use Disorder trials