Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers

Inclusion Criteria: * Age between 18 and 60 years * Adequate oral and dental hygiene * Prolonged positive response to cold test and electric pulp testing * Clinical diagnosis of symptomatic irreversible pulpitis and symptomatic apical periodontitis in a first or second molar (maxillary or mandibular) * Pulp exposure during caries removal accompanied by severe and profuse hemorrhage * No radiographic evidence of periapical lesions * Teeth with adequate restorative potential * Absence of periodontal disease Exclusion Criteria: * Teeth that are non-restorable * Presence of endodontic-periodontal (endo-perio) lesions * Teeth with radiographic evidence of periapical lesions * Teeth with internal or external root resorption * Patients with systemic diseases classified as ASA II or higher * Patients with a history of migraine * Teeth with over-obturation or under-obturation greater than 2 mm from the radiographic apex * Patients taking anti-anxiety medications * Procedural duration exceeding two hours * Known allergy to materials used in root canal treatment, including local anesthetics