Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers (NCT07434141) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers
Iran75 participantsStarted 2025-06-08
Plain-language summary
The goal of this clinical trial is to compare post-treatment pain after root canal therapy in adults with irreversible pulpitis using different root canal sealers. The study will also evaluate the need for pain medication after treatment.
The main questions this study aims to answer are:
Does the type of root canal sealer affect the intensity of pain after treatment?
Does the type of sealer influence the number of analgesic tablets taken by participants?
How does pain change over time after treatment with different sealers?
Researchers will compare two bioceramic sealers (EndoSeal TCS and NeoSeal) with a resin-based sealer (AH Plus) to determine their effects on post-endodontic pain.
Participants will:
Receive root canal treatment using one of the study sealers
Report their pain intensity at specific time points after treatment
Record the number of analgesic tablets taken during the follow-up period
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 60 years
* Adequate oral and dental hygiene
* Prolonged positive response to cold test and electric pulp testing
* Clinical diagnosis of symptomatic irreversible pulpitis and symptomatic apical periodontitis in a first or second molar (maxillary or mandibular)
* Pulp exposure during caries removal accompanied by severe and profuse hemorrhage
* No radiographic evidence of periapical lesions
* Teeth with adequate restorative potential
* Absence of periodontal disease
Exclusion Criteria:
* Teeth that are non-restorable
* Presence of endodontic-periodontal (endo-perio) lesions
* Teeth with radiographic evidence of periapical lesions
* Teeth with internal or external root resorption
* Patients with systemic diseases classified as ASA II or higher
* Patients with a history of migraine
* Teeth with over-obturation or under-obturation greater than 2 mm from the radiographic apex
* Patients taking anti-anxiety medications
* Procedural duration exceeding two hours
* Known allergy to materials used in root canal treatment, including local anesthetics
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Post-Endodontic Pain Intensity
Timeframe: Pain will be assessed at 6, 12,18, 24, and 48 hours post-treatment