Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals (NCT07433972) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals
Thailand60 participantsStarted 2026-03-01
Plain-language summary
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dualt ask gait training in sub-acute (at least 2 weeks after stroke onset) to chronic stroke (within 5 years post-stroke) to investigate changes in brain hemodynamics (oxy-hemoglobin and deoxy-hemoglobin concentration) as measured by functional near infrared spectroscopy (fNIRS). The findings may provides insights changes in combining tES with rehabilitation on improvements in brain hemodynamics in sub-acute to chronic stroke.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Unilateral stroke individuals aged 18-80 years.
✓. A first-ever stroke.
✓. Stroke onset from at least 2 weeks-5 years.
✓. Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)
✓. Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.
✓. Ability to read, communicate, follow and understand instructions.
Exclusion criteria
✕. Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury
✕. Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)
✕. Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture
What they're measuring
1
Blood oxygen level
Timeframe: Baseline, Post-intervention, 1-month follow-up and 3-month follow-up