RecruitingNot Applicable

Prefrontal Neuroplasticity and Coping Strategies in Healthy Population

China42 participantsStarted 2026-01-17

Plain-language summary

The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18-60 years old; Exclusion Criteria: * a family history of psychiatric disorders; * history of or currently diagnosed neuropsychiatric conditions; * history of or active systemic illnesses such as cancer, epilepsy, diabetes, hypertension, or other medical conditions; * contraindications to transcranial magnetic stimulation (TMS); * any prior exposure to brain stimulation procedures.

What they're measuring

iTBS induced prefrontal cortex activity and connectivity

Timeframe: 3 minutes before, during, and after the stimulation

Trial details

NCT IDNCT07433829

SponsorThe Hong Kong Polytechnic University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-30

Contact for this trial

Georg Kranz, PhD

+85227664838 Georg.kranz@polyu.edu.hk

View on ClinicalTrials.gov More Health Adult Subjects trials