This study recruits women from early-mid pregnancy and later follows their children after birth, tracking both the mother and child until the child reaches at least 4 years of age. The study aims to examine the determinants of maternal mental health during pregnancy and how genetic factors could influence maternal mental health and child outcomes.
Who can participate
Age range
21 Years – 40 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Mothers aged 21 - 40 years
. Below 24 weeks of pregnancy by ultrasonography
. Proficient and able to respond to questionnaires in English
. Intends for herself and her child to stay in Singapore for the next 5 years
. Access to a smartphone or standard laptop/desktop
. All participants whose data on pregnancy follow-up and delivery would be available from healthcare professionals
. Willing to take part in this study and able to provide written consent
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Cumulative psychosocial risk index of maternal depression and anxiety
Timeframe: From pregnancy up to 2 years postnatal
2
Polygenic risk score for differential susceptibility to environmental susceptibility
Timeframe: From pregnancy up to 2 years postnatal
3
Determinants of maternal symptoms of depression and anxiety with those that predict positive maternal mental health
Timeframe: From pregnancy up to 2 years postnatal
Trial details
NCT IDNCT07432217
SponsorInstitute for Human Development and Potential (IHDP), Singapore