Not Yet RecruitingPhase 4

Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA

150 participantsStarted 2026-01-31

Plain-language summary

Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours, as well as at the postoperative opioid consumption after 72 hours.

Who can participate

Age range18 Years – 89 Years

SexALL

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Inclusion Criteria: Males or females aged 18-89 years Diagnosed with knee osteoarthritis requiring surgical intervention Indicated for unilateral RATKA Exclusion Criteria: Pediatric, pregnant, or incarcerated patients BMI of more than 45 kg/m2 Prolonged opioid use history of \>5 mg/day for \>1 month History of contralateral TKA \<2 years prior to the index TKA Type 1 Hypersensitivity to NSAIDs or local anesthetics Diagnosis of severe renal disease

What they're measuring

Amount of opioid medications used (measured in morphine milligrams equivalents)

Timeframe: From completion of surgery to 3 days post-op

Patient reported outcome measure (Numeric Rating Scale)

Timeframe: From completion of surgery to 3 days post-op

Trial details

NCT IDNCT07430085

SponsorAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-01-31

Contact for this trial

Obinna Ajah, MD

877-660-6777 obinna.ajah@ahn.org

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