Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and B… (NCT07430007) | Clinical Trial Compass
RecruitingNot Applicable
Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.
Finland158 participantsStarted 2025-10-30
Plain-language summary
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term randomized controlled trial evidence with objective AF burden assessment and advanced cardiac imaging is limited.
The MOVE-AF trial is a randomized controlled trial designed to evaluate whether a 12-month tailored exercise and dietary lifestyle intervention, compared with usual care, reduces atrial fibrillation burden and symptom severity and decreases cardiac and total body fat mass in overweight and obese adults with paroxysmal or persistent AF.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-75 years
* Body mass index (BMI) ≥27 kg/m²
* Documented atrial fibrillation (paroxysmal or persistent)
* Ability to participate in exercise training and follow study procedures
* Access to a smartphone or device enabling rhythm monitoring
* Provides written informed consent
Exclusion Criteria:
* Permanent atrial fibrillation
* Unstable angina pectoris or acute coronary syndrome within the past 3 months
* Participation in other lifestyle or drug weight reduction trials
* Significant left ventricular dysfunction (ejection fraction \<30%)
* Severe valvular heart disease or planned cardiac surgery
* Severe heart failure (NYHA class IV) or severe angina (CCS class IV)
* Unstable coronary artery disease or recent myocardial infarction
* Severe pulmonary disease limiting exercise capacity
* Active malignancy
* Autoimmune or systemic inflammatory diseases
* Severe renal or hepatic failure
* Memory disease or significant cognitive impairment
* Unstable psychiatric condition
* Recent joint or back surgery within the past 6 months
* Continuing back or joint pain symptoms and inability to take part in individualized exercise training
* Contraindications to exercise testing or training, including cardiac symptoms or cardiovascular symptoms, making exercise unsafe
* Pregnancy or breastfeeding
* Participation in another interventional study
* Any condition judged by investigators to make participation unsafe or infeasible
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.