RecruitingNot Applicable

Combined Tibial Nerve Stimulation and Standing for People With SCI

Canada12 participantsStarted 2026-04-02

Plain-language summary

The goal of this clinical trial is to understand how sensory inputs from the lower leg can influence pelvic floor muscle function and urogential function in adults with chronic spinal cord injury (SCI). The main questions it aims to answer are: 1. What is the modulatory role of load and posture on reflex activation of the pelvic floor muscles in participants with SCI? 2. What is the feasibility of combining tibial neuromodulation with standing therapy in participants with SCI? 3. What are the potential effects of combined tibial neuromodulation and standing therapy on reflex excitability and urogential symptoms and quality of life in people with SCI? Participants will be asked complete a series of assessments (questionnaires, electrophysiological testing) before and after a 12-week intervention of combined standing and tibial nerve stimulation therapy.

Who can participate

Age range

19 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 19 years of age * Have a SCI between C7 - T10 that occurred at least 12 months previously * Have a motor-complete or incomplete SCI (AIS A, B, C, or D) * Have symptoms of neurogenic LUT dysfunction * Meet the manufacture requirements for standing frame use (will be evaluated by the research team) * Are able to speak and understand English. Exclusion Criteria: * Have changed their bladder management program in the past month * Have received an injection of Botulinum toxin-A in any LUT structure in the past 2 weeks, or intend to receive an injection while participating in the trial * Have a non-stable SCI (e.g. spinal tumor) * Have signs of a lower motoneuron injury (e.g. cauda equina syndrome) * Have other neurological injury besides SCI * Have an implanted metallic or electronic device (e.g. pace maker, nerve stimulator) * Have a condition for which exercise or transcutaneous stimulation is contraindicated * Have a severe acute medical issue that in the investigator's judgement would adversely affect the participant's participation in the study. Examples include, but are not limited to acute urinary tract infections, pressure sores, musculoskeletal injury, or unmanage blood pressure. * Are currently pregnant or have given birth within the past 12 months * Use walking as your primary means of movement around your home and the community.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Pelvic Floor Muscle Reflex Excitability

Timeframe: At baseline to within 2 weeks of completing the study intervention

Trial details

NCT IDNCT07429305

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

Contact for this trial

Yao Sun, PhD

604-675-8815 lamlab@icord.org

View on ClinicalTrials.gov More Spinal Cord Injury trials