Characterization of the Neural Bases of Mental Imagery in Individuals With Borderline Personality… (NCT07428200) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Characterization of the Neural Bases of Mental Imagery in Individuals With Borderline Personality Disorder: An EEG Study
France62 participantsStarted 2026-03-01
Plain-language summary
Borderline Personality Disorder (BPD) involves altered social cognition, notably dysfunctional processing of cues signaling potential social exclusion and heightened social pain. This study uses EEG during a controlled Cyberball task to test whether BPD patients show a functionally altered social-pain network, particularly increased theta activity, when experiencing induced social exclusion.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* For patients, a diagnosis of borderline personality disorder (established by a board-certified psychiatrist during a structured interview using the MINI) based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)
* For healthy individuals, no psychiatric disorders according to the DSM-5 (except for tobacco use)
* Must be between 18 and 40 years old
* Must provide a signed, free, and informed consent form
* To be affiliated with a social security scheme in France or to be a beneficiary of such a scheme
Exclusion Criteria:
* Known neurological disorders (patient group and control participants)
* Comorbid psychiatric disorders (e.g., current depressive episode; ADHD treated with methylphenidate; bipolar disorder)
* Active substance use disorder (excluding tobacco)
* Pregnancy or breastfeeding
* Guardianship
* Consuming more than three alcoholic drinks in the past 24 hours
* Consuming alcohol on the day of the experiment
* Consuming tea or coffee less than one hour before the experiment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Theta oscillation power in brain regions associated with social pain (e.g., frontal cortex, insula, ACC).
Timeframe: From enrollment to the unique visit which last 2 hours. Cyberball Game during EEG: duration about 20 minutes