Not Yet RecruitingNot Applicable

Chronic Kidney Disease Associated Diet

Turkey (Türkiye)100 participantsStarted 2026-04-20

Plain-language summary

The goal of this observational study is to investigate the relationship between chronic kidney disease (CKD) and periodontitis, and to evaluate the potential mediating role of dietary inflammatory potential, measured by the Dietary Inflammatory Index (DII), in this association. The main question it aims to answer is: Does a pro-inflammatory diet, as reflected by a higher DII score, exacerbate periodontal inflammation in individuals with chronic kidney disease? Participants will include adults diagnosed with CKD at various stages. Periodontal status will be assessed through clinical parameters such as probing depth, clinical attachment loss, and bleeding on probing. Dietary intake will be evaluated using a validated food frequency questionnaire, and DII scores will be calculated accordingly. The study will aim to observe and analyze whether dietary inflammation contributes to increased periodontal disease severity in CKD patients, potentially offering insight into modifiable risk factors relevant to both systemic and oral health.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Being between 18 and 65 years of age * Being diagnosed with Chronic Kidney Disease (having an eGFR below 60 ml/min/1.73 m² for at least 3 months or a urine albumin-to-creatinine ratio above 30 mg/g (proteinuria)) * Having at least 20 teeth * Not having received periodontal therapy in the last 6 months * Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks * Not having any autoimmune disease, osteoporosis, or cancer * Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates * Not being pregnant * Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS) * Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin) * Not taking antioxidant supplements in the last 6 months Exclusion Criteria: * Patients with an active infectious disease, * Those taking medications that could affect periodontal tissues, * History of endocarditis, * Recent antibiotic use (within 4 months), * Alcohol/drug use, * Psychological disorders, * Eating disorders, * Dementia, * Pregnancy and breastfeeding, * Patients who did not sign the informed consent form

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Dietary Inflammatory Index

Timeframe: Day 1

Trial details

NCT IDNCT07427069

SponsorRecep Tayyip Erdogan University Training and Research Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-10-19

Contact for this trial

Oguz KOSE, Professor Dr.

+90 541 348 64 65 oguz.kose@erdogan.edu.tr

View on ClinicalTrials.gov More Chronic Kidney Disease trials