Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration (NCT07426016) | Clinical Trial Compass
RecruitingNot Applicable
Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration
United States100 participantsStarted 2026-06-11
Plain-language summary
Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?
Who can participate
Age range
0 Hours – 3 Days
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Infants born ≤28 weeks GA successfully resuscitated in the delivery room (DR) and maintained on CPAP • Need for surfactant in the first 36 hours of life based on clinical assessment and/or meeting threshold per unit protocol
Exclusion Criteria:
* Infants born ≥29 weeks GA or
* Infants with known congenital anomalies or
* Infants who are determined by the primary care team to receive comfort care only or
* Infants who are intubated at any time prior to surfactant administration
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing two different ways of placing a thin tube in a newborn's throat to give surfactant — video laryngoscopy versus direct laryngoscopy — so which of these methods does our hospital already use, and how might that affect whether this trial is a good fit for our baby?
2Since this is listed as 'Phase NA,' which typically means it's comparing existing procedures rather than testing a new drug, what are the known risks of each laryngoscopy method being studied, and how do those risks compare for a premature or sick newborn?
3The trial is measuring 'first attempt success rate,' meaning how often doctors get the tube placed correctly on the first try — can you explain what happens to my baby if the first attempt doesn't succeed, and how many attempts are typically allowed before they stop?
4Given that this study involves a procedure done during a medical emergency like respiratory distress, how will the research team get our consent when time may be extremely limited?
5Are there standard-of-care treatments for neonatal respiratory distress syndrome that my baby could receive outside of this trial, and how would enrolling in this study change the treatment decisions made for our baby?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Rate of first attempt success
Timeframe: During procedure
Trial details
NCT IDNCT07426016
SponsorUniversity of Texas Southwestern Medical Center