Optic Nerve Head Strain in Non-glaucoma Subjects (NCT07425535) | Clinical Trial Compass
Not Yet RecruitingEarly Phase 1
Optic Nerve Head Strain in Non-glaucoma Subjects
30 participantsStarted 2026-07
Plain-language summary
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
Who can participate
Age range
30 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults who have no history of OAG
* Have an ocular examination by a glaucoma specialist with no indications of OAG
* Have normal optical coherence tomography findings in the retinal nerve fiber layer.
* Over age 30 will be included from
* Both sexes
* All ethnic groups.
* Optic neuropathy.
* Both suspects and those with glaucoma damage will be included.
* When both eyes meet inclusion and exclusion criteria, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.
Exclusion Criteria:
* in whom sitting in an upright position is impossible due to physical disability
* with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
* in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
* who cannot perform home tonometry accurately at certification
* who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
* with any form of glaucoma
* with high myopia defined as refractive error \> -8
* with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret
* inability to understand English or with a language or hearing impairment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.