CompletedNot Applicable

Investigation of the Relationship Between Gray and White Matter Volumes, Walking Exercise, and Body Fat Percentage in Adults With a Body Mass Index Above 25

Turkey (Türkiye)22 participantsStarted 2024-01-01

Plain-language summary

This study examines the relationship between walking exercise, body fat percentage changes, and brain gray and white matter volumes in overweight and obese adults with headache complaints. Participants with a Body Mass Index (BMI) of 25 or above will be divided into two groups: one receiving a diet program combined with a 12-week walking exercise regimen, and a control group receiving diet alone. Both groups will undergo brain MRI scans and body composition measurements at baseline and after 12 weeks. The study aims to determine whether exercise-induced reductions in body fat percentage have a measurable impact on brain structure, specifically gray and white matter volumes. Blood tests will monitor metabolic markers throughout the intervention. This research may contribute to understanding how different types of exercise affect brain health and inform the development of more effective treatments for obesity-related neurological changes.

Who can participate

Age range19 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Adults aged 19-65 years
✓. Body Mass Index (BMI) ≥25 kg/m²
✓. Presented to the neurosurgery department with headache complaints between January 1, 2024 and March 1, 2024
✓. Underwent brain magnetic resonance imaging (MRI) between January 1, 2024 and March 1, 2024
✓. Completed baseline blood tests between January 1, 2024 and March 1, 2024, including:
✓. Scheduled for routine 6-month follow-up blood work based on initial test results
✓. Willing to undergo follow-up brain MRI at 12 weeks (costs covered by research team)
✓. Willing and able to attend 6 biweekly nutrition counseling sessions over 12 weeks with the study dietitian

Exclusion criteria

✕. Did not present to the neurosurgery department with headache complaints between January 1, 2024 and March 1, 2024

What they're measuring

Change in Brain Gray Matter Volume

Timeframe: Baseline and 12 weeks

Change in Brain White Matter Volume

Timeframe: Baseline and 12 weeks

Trial details

NCT IDNCT07425093

SponsorAmasya University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-01

View on ClinicalTrials.gov More Obesity & Overweight trials