Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury. This prospective, single-centre observational cohort study will evaluate perioperative dynamics of serum biomarkers of neuronal, glial, and axonal injury and relate biomarker patterns to postoperative EEG changes and brain MRI findings, aiming to improve early detection of brain injury and identify children at higher risk of hypoxic encephalopathy.
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Concentration of serum brain injury biomarker concentrations (ELISA panel)
Timeframe: Within 24 hours pre-op; 1 hour post-op arrival; 24, 48, 72, 96 hours; and 7 days post-op.
Number of Participants with postoperative EEG abnormalities
Timeframe: Post-op day 0-1 and post-op day 7
Presence and types of intracranial injuries seen on brain MRI (subset)
Timeframe: Post-op week 1-2.