CompletedNot Applicable

Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy

Turkey (Türkiye)101 participantsStarted 2024-12-03

Plain-language summary

This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis. A total of 101 patients were evaluated before and after routine nonsurgical periodontal therapy. Volatile sulfur compound (VSC) levels and psychophysical olfactory performance using the Sniffin' Sticks test (TDI score) were measured at baseline and one week after completion of three sessions of scaling and root planing (SRP). The study aimed to determine whether reduction of oral inflammation and halitosis is associated with improvement in olfactory performance.

Who can participate

Age range

18 Years – 55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Inclusion Criteria: * Adults aged 18-55 years * Diagnosis of generalized periodontitis * Complaint of halitosis * At least 15 natural teeth Exclusion Criteria: * Self-reported smell loss or change within 2 weeks prior to baseline * Antibiotic or anti-inflammatory drug use for more than 7 days within the previous 6 weeks * Presence of upper respiratory tract infection * Unrestored advanced dental caries * History of COVID-19 infection * Pregnancy Smoking was not an exclusion criterion.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Total TDI Score

Timeframe: Baseline to 1 week after completion of third SRP session (approximately 4 weeks total)

Change in Total Volatile Sulfur Compound (tVSC) Levels

Timeframe: Baseline to 1 week after completion of third SRP session

Trial details

NCT IDNCT07424300

SponsorBatman University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-03-20

View on ClinicalTrials.gov More Periodontitis trials