The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults (NCT07424170) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults
140 participantsStarted 2026-03-15
Plain-language summary
The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are:
Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.
Who can participate
Age range
65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged ≥ 65 years;
* Classified as ASA physical status I to III;
* Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia;
* Expected surgical duration of at least 2 hours;
* Voluntarily provide written informed consent and agree to participate in this study.
Exclusion Criteria:
* Significant change in exercise status within the past 7 days due to injury or other reasons;
* Contraindications to neuraxial anesthesia;
* Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score \< 23;
* Preoperative diagnosis of delirium;
* History of traumatic brain injury or neurosurgery;
* Long-term opioid use or history of alcohol abuse;
* Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration);
* Change in anesthesia method.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.