Acute Effects of LLLT on Pain Threshold and Pain Tolerance (NCT07422272) | Clinical Trial Compass
CompletedNot Applicable
Acute Effects of LLLT on Pain Threshold and Pain Tolerance
Cyprus62 participantsStarted 2025-12-15
Plain-language summary
Pain is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Low-Level Laser Therapy (LLLT) has gained attention as a safe, noninvasive intervention with analgesic and anti-inflammatory effects. This study examines whether a single session of LLLT can produce immediate changes in pain threshold and pain tolerance in healthy adults, compared to a sham laser control.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 35 years
* Healthy individuals without chronic medical conditions
* Free from chronic or acute pain
* All genders
* Able to provide informed consent
Exclusion Criteria:
* Menstruation at the time of testing
* Sensory deficits (failure to pass sharp-dull test)
* Pregnancy
* History of epilepsy
* Presence of cardiovascular conditions (including pacemaker)
* Acute hand injuries
* Diagnosed neurological disorders
* Use of analgesics or NSAIDs within the previous 48 hours
* Contraindications to low-level laser therapy or electrical stimulation (e.g., light sensitivity, malignancy)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Electrical Pain Threshold Intensity (mA)
Timeframe: Pre-intervention and immediately post-intervention
2
Electrical Pain Tolerance Intensity (mA)
Timeframe: Pre-intervention and immediately post-intervention