The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device, 2. Identify the mechanism/s of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and 3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO. For the study there are three separate visits: 1. Free running with the device on the neck 2. Exercise treadmill study 3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.
Age range
18 Years – 26 Years
Sex
ALL
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Device measurements from real time running
Timeframe: Baseline and Periprocedural
Device measurements from real time running
Timeframe: Baseline and Periprocedural
Device measurements from real time running
Timeframe: Baseline and Perioprocedural
Treadmill testing
Timeframe: Baseline and Perioprocedural
Treadmill testing
Timeframe: Base-line
Treadmill testing
Timeframe: Breath-by-breath baseline and Perioprocedural
Treadmill testing
Timeframe: Baseline and Periprocedural
MRI Upper Airway Size
Timeframe: Baseline
Upper Airway Aerodynamics
Timeframe: Baseline and Periprocedural
Upper Airway Aerodynamics
Timeframe: Baseline and Periprocedural
Upper Airway Aerodynamics
Timeframe: Baseline and Periprocedural