Artificial Intelligence or Human Hand? Evaluating Inferior Vena Cava Imaging for Hydration Status (NCT07419048) | Clinical Trial Compass
RecruitingNot Applicable
Artificial Intelligence or Human Hand? Evaluating Inferior Vena Cava Imaging for Hydration Status
Switzerland50 participantsStarted 2026-02-02
Plain-language summary
This observational pilot project is to compare AI-guided sonographic IVC measurements with those of human operators (experienced sonographer, beginner sonographer) in two commonly used views (Subcostal (SC)), Right Intercostal (RI)) in healthy, euvolemic participants before and after PLR, which mimics hypervolemia, in order to assess the possible role of AI-guided sonographic IVC measurements by assessing its feasibility and reliability.
Each participant will undergo a SC and a RI IVC US assessment before and after PLR by both sonographers, resulting in a total of 8 IVC US examinations with 8 additional AI-guided IVC indices assessments.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy adults aged 18 years or older, 50% biological women
Exclusion Criteria:
* Pregnant or lactating women
* History of thrombosis of the inferior vena cava
* Major cardiovascular event in the last 3 months
* History of peripheral arterial disease of the legs
* History of heart failure of any grade
* History of atrial fibrillation or atrial flutter
* History of severe valvular disease
* History of renal failure
* History of liver cirrhosis
* History of chronic obstructive lung disease (COPD), chronic bronchitis, pulmonary emphysema
* History of diabetes mellitus
* History of arginine-vasopressin (AVP) disturbance
* Abdominal surgery within the last 3 month
* Volume loss (diarrhoea, vomiting, or bleeding) within the past 3 days
* Respiratory distress of any grade
* Any diuretic therapy, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs)
* Inability to follow procedures or insufficient proficiency in the study language
* Inability to provide informed consent
* Vital signs outside normal limits: tachycardia \>100 bpm, systolic blood pressure \<85 mmHg, or SpO2 \< 92%
* Employees or colleagues in a direct supervisory, subordinate, or collaborative relationship with the study team
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Percentage of participants with IVC max >2.1 cm and IVC CI <50% in the SC view
Timeframe: These assessments will take place on the same day; the study visit will last about 60 minutes