Tourette Syndrome (TS) children were administered Pei Tu Ning Feng Tang treatment. The differences in gut microbiota composition, peripheral blood stress hormones, oxidative stress markers, cytokines, neurotransmitters, and hair cortisol concentrations were observed before and after treatment. Combined with the differences in tic-like behavioral indicators, the therapeutic efficacy of Pei Tu Ning Feng Tang was evaluated. Additionally, TS children underwent two fNIRS examinations before and after treatment to quantitatively describe the activation of brain function by Pei Tu Ning Feng Tang and to investigate its neural mechanisms against tics. Scores were assessed before and after treatment using the Yale Global Tic Severity Scale (YGTSS) and the Traditional Chinese Medicine Syndrome Score Sheet for Pediatric Tourette Syndrome (Spleen Deficiency and Liver Hyperactivity Type) to observe the efficacy of the medication.
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Functional near-infrared spectroscopy (fNIRS) was used to detect the degree of brain function activation.
Timeframe: From enrollment to the end of the one-month treatment period
Relative and absolute quantitative analysis of the gut microbiota.
Timeframe: From enrollment to the end of the one-month treatment period
Determination of Short-Chain Fatty Acids in Feces
Timeframe: From enrollment to the end of the one-month treatment period
Analysis of Stress Hormones
Timeframe: From enrollment to the end of the one-month treatment period
Analysis of Oxidative Stress Markers
Timeframe: From enrollment to the end of the one-month treatment period
Analysis of Cytokines
Timeframe: From enrollment to the end of the one-month treatment period
Concentration of Neurotransmitters
Timeframe: From enrollment to the end of the one-month treatment period