Validation of NAD+ Measurements for Human Clinical Studies (NCT07416786) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Validation of NAD+ Measurements for Human Clinical Studies
United States48 participantsStarted 2026-07-01
Plain-language summary
The purpose of this study is to determine nicotinamide adenine dinucleotide (NAD) levels in healthy adult subjects before and after supplementing with over-the counter nicotinamide riboside (NR) using magnetic resonance spectroscopy (MRS).
Who can participate
Age range
18 Years – 110 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* Male or female age18-35 years or 70 years or older, healthy
* if female reproductive potential, use of highly effective contraception (at least 1 month prior to screening and during study participation).
* No known sensitivity to NR
* No use of niacin, blood thinners or chemotherapy agents
* HbA1c below 8.5% and not diabetec requiring insulin.
* Not using/taking corticosteroids
* No laboratory abnormalities indicating significant anemia, bleeding risk, kidney disease, or liver disease
* No contraindication to MRI
* Not Pregnant, lactating, or planning to become pregnant during participation
* Not taking multivitamins or any over-the-counter supplements except calcium and vitamin D (any other supplements - discontinued 2 weeks prior to study participation).
* not taking/ undergoing another investigational drug or other intervention within the past 30 days.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Nicotinamide adenine dinucleotide (NAD) measurement in brain MRI
Timeframe: Before supplementation and after 4 weeks (-3 days, +7days) of supplementation with nicotinamide riboside (NR)
2
NAD measurement of calf MRI
Timeframe: Before supplementation and after 4 weeks (-3 days, +7days) of supplementation with nicotinamide riboside (NR)