Not Yet RecruitingNot Applicable

PPV vs PVI in the Supine and Prone Position

100 participantsStarted 2026-06

Plain-language summary

This is a prospective study that will record the Pulse Pressure Variability (PPV) from the arterial line and Plethysmography Variability Index (PVI) from the pulse oximeter while the patient is in the supine position and then again in the prone position. There will be no change in anesthetic care based on the study protocol. The primary objective of this study is to evaluate the changes in PVI and PPV when changing from the supine and prone position in pediatric-aged patients.

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Consenting ASA 1-4 patients * Undergoing a surgical procedure with general anesthesia that requires placement of an arterial cannula and prone positioning Exclusion Criteria: * Patients in whom an arterial cannula is not indicated or cannot be placed * Patients undergoing a surgical procedure that does not require prone positioning

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

PPV Supine

Timeframe: Once a minute for 5 minutes

PVI Supine

Timeframe: Once a minute for 5 minutes

PPV Prone

Timeframe: Once a minute for 5 minutes

PVI Prone

Timeframe: Once a minute for 5 minutes

Trial details

NCT IDNCT07415603

SponsorJoseph D. Tobias

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2029-05-31

Contact for this trial

Julie Rice-Weimer, BSN

614-355-3142 julie.rice-weimer@nationwidechildrens.org

View on ClinicalTrials.gov More Surgeries Undergoing General Anesthesia trials

Plain-language summary

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.