Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy (NCT07415148) | Clinical Trial Compass
CompletedNot Applicable
Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy
Turkey (Türkiye)51 participantsStarted 2025-04-09
Plain-language summary
Periodontitis is a chronic inflammatory disease that leads to the destruction of the supporting tissues of the teeth. Non-surgical periodontal treatment is the first-line approach for the management of periodontitis; however, the use of adjunctive therapeutic agents may improve clinical outcomes.
The aim of this randomized clinical trial is to evaluate the effects of hyaluronic acid gel and albumin platelet-rich fibrin (Alb-PRF) used as adjuncts to non-surgical periodontal treatment on clinical and biochemical parameters in patients with Stage III periodontitis. Participants will be randomly allocated into three groups: an Alb-PRF group, a hyaluronic acid gel group, and a control group receiving non-surgical periodontal treatment alone. Clinical periodontal parameters and biochemical markers obtained from gingival crevicular fluid will be assessed at baseline and at 1 and 3 months after treatment. The findings of this study are expected to contribute to the evaluation of the potential benefits of adjunctive biological and anti-inflammatory applications in the non-surgical periodontal treatment of patients with Stage III periodontitis.v
Who can participate
Age range
30 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Systemically healthy individuals aged between 30 and 60 years
* No history of periodontal treatment or antibiotic use within the last 6 months
* Non-smokers
* Accepting to regularly attend the follow-up sessions planned during the study period
* Diagnosis of Stage III periodontitis
* Presence of at least 15 teeth in the oral cavity, with more than 30% of the existing teeth affected by periodontal disease
* Presence of probing pocket depth ≥6 mm and clinical attachment loss ≥5 mm in affected teeth
* Presence of vertical bone loss ≥3 mm
* Radiographic evidence of alveolar bone loss extending to the middle third or beyond (≥33%) of the root length in affected teeth
Exclusion Criteria:
* Presence of any systemic disease
* History of periodontal treatment or antibiotic use within the last 6 months
* Pregnancy or lactation
* Presence of acute oral lesions or necrotizing ulcerative periodontitis
* Use of medications known to affect periodontal tissues
* Current smoking
* Presence of immune system disorders or use of immunosuppressive medications
* Presence of prosthetic restorations on teeth selected for gingival crevicular fluid sampling
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Gingival Crevicular Fluid VEGF Levels
Timeframe: Baseline, 1. month and 3. months
2
Change in Gingival Crevicular Fluid IL-1 Beta Levels