Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4

Inclusion Criteria: * Willing to sign a written participant consent form. * Males or females aged 40 or above who have participated in the "Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging (Pilot Project)," the "Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging" master planner, or the "Integrated Systematic Medical Information to Explore Solutions for Healthy Aging" project (not subject to exclusion criteria). * Males or females aged 40-59 who have participated in health checkups for employees of Chang Gung Memorial Hospital, Formosa Plastics Group, or Chang Gung University. * Those with a medical record of more than one year at Chang Gung Memorial Hospital. * Those who have resided in Taiwan for more than 180 days in the past year. Exclusion Criteria: * Individuals with severe organ abnormalities, such as: heart failure (NYHA Fc ≥ III), chronic obstructive pulmonary disease (hospitalization/emergency room visit or medication adjustment within the past month due to disease worsening), decompensated cirrhosis, hemodialysis, or currently undergoing cancer treatment. * Individuals with a history of severe autoimmune diseases. * Individuals with a preliminary cognitive and mental assessment score of \<26 on the Mini-Mental State Examination (MMSE) or ≥5 on the Generalized Depression Scale (GDS). * Individuals (who agree to undergo brain MRI) who are deemed unsuitable for MRI after evaluation (e.…