6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing … (NCT07414173) | Clinical Trial Compass
RecruitingPhase 4
6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health
Germany90 participantsStarted 2026-01-28
Plain-language summary
The goal of this clinical trial is to evaluate the clinical efficacy of an antimicrobial mouthrinse, with a particular focus on its effect on established plaque and the improvement of gum health.
Participants will:
* Brush and rinse twice a day with the designated products for 6 months
* Visit the clinic once every 3 months after baseline for reassessment.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Male and female subjects aged 18-70 years, inclusive.
✓. Availability for the 6-month duration of the clinical research study.
✓. Good general health based on the opinion of the study investigator.
✓. Signed Informed Consent Form.
✓. Minimum of 20 natural teeth (excluding third molars).
✓. Initial gingivitis index of at least 1.5 as determined by the use of the Loe and Silness Gingival Index.
✓. Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification).
Exclusion criteria
✕. Be under orthodontic treatment.
✕. Presence of partial removable dentures.
✕. Tumor(s) of the soft or hard tissues of the oral cavity.
✕. Participants with current moderate or severe periodontitis (periodontitis screening index \[PSI\] \>2 in more than 2 sextants or PSI \>3), and/or purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone.
✕. Five or more carious lesions requiring immediate restorative treatment.
✕. Antibiotic use any time during the one-month period prior to entry into the study.
What they're measuring
1
Improvement of gum health as measured by the Gingival Index (Löe 1967) between the study groups.