Turning Ratios Into Prognosis: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powe… (NCT07414056) | Clinical Trial Compass
RecruitingNot Applicable
Turning Ratios Into Prognosis: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powerful Predictors of ARDS in Pediatric Burn Patients: A Prospective Evaluation
Egypt60 participantsStarted 2025-11-10
Plain-language summary
The aim of this study is to evaluate the role of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as predictors for development of ARDS in pediatric burn patients.
Who can participate
Age range1 Year – 12 Years
SexALL
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Inclusion Criteria:
* Age 1-12 years.
* Patients presenting within 24 hours of burn injury.
* Patients presenting with severe burns 20-40% of total body surface area (TBSA).
* Thermal burns or scalds.
* Both sexes.
Exclusion Criteria:
* Patient refusal to participate in the trial.
* Age \<1 \& \>12 years.
* Delayed admission \>24h post-injury.
* Patients presenting with burns \<20% or \>40% of TBSA.
* Non-thermal burns.
* Associated medical comorbidities: Chronic liver or kidney diseases, anemia.
* Preexisting chronic lung disease (e.g., cystic fibrosis, severe bronchopulmonary dysplasia).
* Inflammatory conditions (e.g., inflammatory bowel disease).
* Immunocompromised individuals, autoimmune diseases, those undergoing treatment with immunosuppressants, corticosteroids, cytotoxic chemotherapy.
* Known malignancies, hematologic malignancy or conditions altering WBC/platelets significantly.
* Previous malnutrition.
* Immunosuppressive therapy prior to admission (e.g., chronic steroids).
What they're measuring
1
Neutrophil to Lymphocyte ratio (NLR) and Platelet to Lymphocyte ratio (PLR) for acute respiratory distress syndrome (ARDS) prediction using the Pediatric Index of Mortality 2 score (PIM2 score).