CompletedNot Applicable

Tabata Exercise on Nitric Oxide Synthases and Maresin

Turkey (Türkiye)40 participantsStarted 2025-10-24

Plain-language summary

Smoking causes chronic inflammation and endothelial dysfunction through alterations in nitric oxide synthase (NOS) pathways. Maresin is an anti-inflammatory pro-resolving lipid mediator that plays important roles in the resolution of inflammatory processes. Tabata exercise is a short-duration, high-intensity exercise modality with beneficial effects on the cardiovascular system. The aim of this study was to comparatively evaluate the effects of tabata exercise on iNOS, eNOS, and Maresin levels, as well as the relationships among these biomarkers, in smokers and non-smokers.

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 18 and 40 years * No regular participation in structured physical exercise for at least 6 months prior to enrollment * Absence of any acute or chronic inflammatory disease at baseline * No history of cardiovascular, metabolic, pulmonary, or neurological disorders * Ability to comply with the study protocol and complete the tabata exercise program * Provision of written informed consent Exclusion Criteria: * Initiation or cessation of smoking during the study period * Use of anti-inflammatory, antioxidant, corticosteroid, or vasoactive medications * Acute infection, surgical intervention, or major trauma within the preceding 3 months * Diagnosis of diabetes mellitus, hypertension, coronary artery disease, or chronic pulmonary disease * History of alcohol or substance abuse * Pregnancy or breastfeeding * Musculoskeletal or orthopedic conditions that could limit participation in tabata exercise * Inability to adhere to the exercise protocol or failure to complete follow-up assessments

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

serum inducible nitric oxide synthase (iNOS) level

Timeframe: 6 week after exercise

serum inducible nitric oxide synthase (iNOS) level

Timeframe: 12 week after exercise

serum endothelial nitric oxide (eNOS) synthase level

Timeframe: 6 week after exercise

serum endothelial nitric oxide (eNOS) synthase level

Timeframe: 12 week after exercise

Trial details

NCT IDNCT07412639

SponsorAtaturk University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-16

View on ClinicalTrials.gov More Smoking trials

Plain-language summary

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

serum inducible nitric oxide synthase (iNOS) level

Timeframe: 6 week after exercise

serum inducible nitric oxide synthase (iNOS) level

Timeframe: 12 week after exercise

serum endothelial nitric oxide (eNOS) synthase level

Timeframe: 6 week after exercise

serum endothelial nitric oxide (eNOS) synthase level

Timeframe: 12 week after exercise