Not Yet RecruitingNot Applicable

Periodontal Health Profile in Multiple Sclerosis Patients

100 participantsStarted 2026-02-03

Plain-language summary

This study aims to evaluate the periodontal status of patients with Multiple Sclerosis (MS) through clinical, microbiological, and biochemical parameters. Multiple sclerosis and periodontal diseases are both chronic inflammatory conditions that may share common immunopathological pathways. The primary objective is to investigate the relationship between MS and periodontal health by comparing clinical measurements with the microbial composition and biochemical markers found in saliva samples of patients followed by the Neurology Department.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria (Test Group): * Voluntarily agreeing to participate in the study. * Being over 18 years of age. * Diagnosed with Multiple Sclerosis (MS) according to the 2017 McDonald criteria. * Being able to communicate clearly and effectively. Inclusion Criteria (Control Group): * Voluntarily agreeing to participate in the study. * Being over 18 years of age. * Not having a diagnosis of Multiple Sclerosis (MS) according to the 2017 McDonald criteria. * Being able to communicate clearly and effectively. Exclusion Criteria (Test Group): * Being under 18 years of age. * Patients whose MS diagnosis is not yet definitive. * Being pregnant or in the lactation (breastfeeding) period. * Having received antibiotic treatment within the last 3 months. * Having received periodontal treatment within the last 6 months. * Patients undergoing radiotherapy or chemotherapy. Exclusion Criteria (Control Group): * Being under 18 years of age. * Being diagnosed with Multiple Sclerosis (MS) according to the 2017 McDonald criteria. * Being pregnant or in the lactation (breastfeeding) period. * Having received antibiotic treatment within the last 3 months. * Having received periodontal treatment within the last 6 months. * Patients undergoing radiotherapy or chemotherapy.

What they're measuring

Clinical Attachment Level (CAL)

Timeframe: Baseline

Probing Pocket Depth (PPD)

Timeframe: Baseline

Plaque Index (PI)

Timeframe: Baseline

Gingival Index (GI)

Timeframe: Baseline

Trial details

NCT IDNCT07412431

SponsorSaglik Bilimleri Universitesi

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-10-05

Contact for this trial

Nuriye Işıl SAYGUN, Professor

+903125671500 nuriyeisil.saygun@sbu.edu.tr

View on ClinicalTrials.gov More Multiple Sclerosis trials

Plain-language summary

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.