Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS)

Inclusion Criteria: * Women aged ≥ 18 years and \< 45 years ; * Discontinuation of estrogen-progestin therapyfor at least 3 months ; * Signed informed consent ; * Social security affiliation. Case (n=25): \- Patient with a lipodystrophic syndrome due to a known pathogenic variant of the LMNA gene. Control (n=50), : \- patient consulting for polycystic ovary syndrome (PCOS according to the Rotterdam criteria) in day hospital matched on age +/-5 years and BMI+/-5 kg/m2. Exclusion Criteria: * \- Severe renal insufficiency (GFR \< 30 ml/min) ; * Hepato-cellular insufficiency (TP \< 50%) ; * Taking corticosteroids or antiretrovirals ; * Menopausal women ; * Taking estrogen-progestin therapy; * Diabetic patients on insulin : type 1 diabetes or pancreatectomised patients * Other known causes of hyperandrogenism (21-hydroxylase block, Cushing's syndrome, ovarian tumor). * Pregnant woman * Breastfeeding woman