Palatal Wound Healing After Free Gingival Graft Surgery (NCT07409571) | Clinical Trial Compass
RecruitingNot Applicable
Palatal Wound Healing After Free Gingival Graft Surgery
Turkey (Türkiye)55 participantsStarted 2025-10-16
Plain-language summary
This randomized controlled clinical trial aims to evaluate the effects of topical triamcinolone acetonide application on wound healing and patient-reported outcomes at the palatal donor site following free gingival graft (FGG) surgery. A total of 55 patients with mucogingival deficiencies requiring FGG will be randomly assigned to either a control group receiving a collagen membrane or a test group receiving topical triamcinolone acetonide at the donor site. All palatal donor areas will be protected with a periodontal dressing. Clinical assessments will be performed on postoperative days 3, 7, 14, and 30. Wound epithelialization will be evaluated using the hydrogen peroxide bubbling test, while wound healing and scar formation will be assessed using the Landry, Turnbull, and Howley index and the modified Manchester Scar Scale, respectively. Patient-centered outcomes, including postoperative pain, discomfort, analgesic consumption, and oral health-related quality of life, will be assessed using visual analog scales and the Oral Health Impact Profile-14 questionnaire. The findings of this study are expected to provide evidence regarding the potential benefits of topical corticosteroid use in reducing palatal donor site morbidity following FGG surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 years and older
* Patients presenting with insufficient attached gingiva and/or gingival recession requiring free gingival graft surgery
* Systemically healthy individuals (ASA I)
* Full-mouth plaque score (FMPS) \< 15% and full-mouth bleeding score (FMBS) \< 15% at the time of surgery
* Ability and willingness to provide written informed consent and comply with study procedures
Exclusion Criteria:
* Presence of systemic diseases that may affect wound healing (e.g., diabetes mellitus, immunological disorders)
* Use of systemic corticosteroids, immunosuppressive drugs, or anti-inflammatory medications within the last 3 months
* Current smokers or tobacco users
* Pregnancy or lactation
* History of periodontal surgery at the palatal donor site
* Presence of active infection, ulceration, or pathological lesions at the palatal donor area
* Known allergy or hypersensitivity to corticosteroids, collagen materials, or study-related medications
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Oral Health-Related Quality of Life
Timeframe: Postoperative Days 3, 7, 14, and 30
2
Number of participants with complete wound epithelialization