Entropy-based Physiological Signal Analysis in Patients With Obstructive Sleep Apnoea (NCT07406620) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Entropy-based Physiological Signal Analysis in Patients With Obstructive Sleep Apnoea
United Kingdom139 participantsStarted 2026-06-11
Plain-language summary
This observational study is being undertaken as a part of a Master of Research (MRes) in Clinical Research programme.
Its goal is to learn about how continuous positive airway pressure (CPAP) therapy changes the complexity of body signals in adults with obstructive sleep apnoea (OSA). The main question it aims to answer is:
\- How does the complexity of physiological signals (specifically oxygen saturation, heart rate, and heart rate variability) change in adults with OSA from before to after three and six months of CPAP treatment?
It will use data from individuals who took part in an earlier trial, called 3DPiPPIn, which tested the use of 3D-printed, customised masks CPAP masks through sleep studies.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participation in the 3DPiPPIn trial
* Completion of the 3DPiPPIn trial to its primary endpoint of six months
* Availability of physiological signal data at baseline, three months, and six months
* Provision of informed consent permitting the use of their data in future research
Exclusion Criteria:
* Non-completion of the 3DPiPPIn trial to its primary endpoint of six months
* Missing physiological signal data at baseline, three months, or six months
* No consent for the use of their data in future research
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in oxygen saturation entropy from pre to six months post CPAP therapy
Timeframe: From baseline to six months post-initiation of CPAP therapy
2
Change in heart rate entropy from pre to six months post CPAP therapy
Timeframe: From baseline to six months post-initiation of CPAP therapy
3
Change in heart rate variability entropy from pre to six months post CPAP therapy
Timeframe: From baseline to six months post-initiation of CPAP therapy