Comparison of C-Reactive Protein Levels in Traumatic Brain Injury Patients Undergoing Craniotomy With and Without Dexmedetomidine

Inclusion Criteria: * Patients aged ≥ 18 years to ≤ 60 years * Patients with secondary brain injury with onset ≥ 6 hours * Patients with a GCS score \> 6 undergoing emergency and elective craniotomy * American Society of Anesthesiologists (ASA) physical status ≥ II * Body mass index \> 17 kg/m² and \< 30 kg/m² Exclusion Criteria: * Patients with head injury onset \< 6 hours * Patients with signs of systemic shock * Patients or family members who refuse to participate * Patients with a history of allergy to dexmedetomidine, sevoflurane, and/or sufentanil * Patients with a history of active infection or sepsis * Patients who have received massive blood transfusion prior to surgery * Patients with autoimmune diseases * Patients with active malignancy * Patients with a history of chemotherapy * Patients with a history of hepatic dysfunction, indicated by elevated alanine aminotransferase (ALT/SGPT) levels above the normal reference range (7-56 U/L) * Patients with a history of long-term corticosteroid therapy * Patients with a history of neuropsychiatric disorders and cognitive impairment * Patients with a history of pre-existing cardiovascular disease * Patients with a history of coagulation disorders