Low Concentration Atropine Combined With Soft Contact Lens in Controlling Myopia Progression in Children With High Myopia

Inclusion Criteria: * Mainland Chinese children aged 4-16 years at enrollment * Spherical equivalent refraction ≤-6.0D in both eyes under cycloplegia * Astigmatism ≤2.5D in both eyes * Anisometropia ≤2.5D * Best corrected visual acuity ≥0.1 logMAR in both eyes * Subject-reported non-significant ocular and systemic medical history * Ability and willingness to wear contact lenses (for intervention groups) * Written informed consent from parents/guardians and assent from child * Ability to attend all scheduled follow-up visits Exclusion Criteria: * Previous use of myopia control treatments (atropine, orthokeratology, multifocal lenses) within 3 months * Current use of systemic medications affecting pupil size or accommodation * Known allergies to atropine or contact lens materials * Current use of systemic medications that may significantly affect contact lens wear, tear film production, pupil size, adaptability, or refractive status. * Ocular diseases: strabismus, amblyopia, glaucoma, cataract, corneal disease * Systemic diseases affecting ocular health * History of ocular surgery or trauma * Inability to perform study procedures * Participation in other clinical trials within 2 months