Effects of Acute Sleep Deprivation on Health (NCT07403864) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Acute Sleep Deprivation on Health
48 participantsStarted 2026-03-01
Plain-language summary
This study will investigate whether various types of regular exercise can provide protective effects against metabolic abnormalities induced by sleep restriction. It will examine responses related to metabolic health, cognitive function, energy expenditure, subjective feelings, and human behaviors, including physical activity and energy intake.
Who can participate
Age range
20 Years – 45 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 20-45 years.
* Body Mass Index (BMI) between 18.5-27 kg/m².
* No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤ 5.
* Usual bedtime between 22:00-01:00, wake-up time between 06:00-09:00, with an average sleep duration of 7 to 9 hours; chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), and no changes in sleep patterns over the past 3 months.
* Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.
* No specific dietary habits, such as intermittent fasting or a ketogenic diet.
* Maintaining a stable weight (no self-reported weight change ± 3 kg) for at least 3 months.
* Resting blood pressure ≤ 130/80 mmHg.
* No smoking or excessive alcohol consumption.
* Not a shift worker.
* No international travel across time zones has occurred within the past 3 months.
Exclusion Criteria:
* Special diets (e.g., intermittent fasting, ketogenic diet)
* Recent injuries or contraindications to intense exercise.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Glycemic Control
Timeframe: Baseline measurements and continuously at regular intervals throughout the 3-hour OGTT.
2
Pulse wave velocity (PWV)
Timeframe: 0 (baseline), 60, 120 and 180 minutes during OGTT
3
Cognitive function (Accuracy)
Timeframe: 0 (baseline), 90 and 180 minutes during OGTT
4
Cognitive function (Reaction time)
Timeframe: 0 (baseline), 90 and 180 minutes during OGTT