The objective of this study is to understand how spatiotemporal and kinetic gait parameters are associated with bone health in pwSMA who are receiving DMT. We hypothesize that gait parameters are associated with BMD and can determine fracture risk in pwSMA. This is an observational study that involves one in-clinic visit (approximately 3 hours) with remote follow-up visits (approximately 15 minutes) every 3 months for 1 year to collect fracture and medical history. Each of the assessments included in this study are non-interventional and are not intended as a treatment nor are they at the level of standard of care.
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Dual X-Ray Absorptiometry (DXA)
Timeframe: Baseline
Blood collection
Timeframe: Baseline
Fracture history
Timeframe: Baseline, months 3, 6, 9, and 12
Fall history
Timeframe: Baseline, months 3, 6, 9 and 12
Collection of spatiotempoal and kinetic gait parameters using instrumented insoles (AI-Sole)
Timeframe: Baseline
Six Minute Walk Test
Timeframe: Baseline
IPAQ-SF
Timeframe: Baseline