Rheumatoid arthritis (RA) is characterized as a systemic auto immune disorder linked to a persistent inflammatory process that can harm both joints and extra articular organs. The upregulation of the CCR6/CCL20 axis in the synovial tissues and salivary glands (in cases of secondary Sjögren's syndrome) is considered to contribute to the recruitment of Th17 cells, which in turn enhances IL 17A production and promotes the inflammatory cycle.
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assess expression of CCR6 gene in peripheral blood leukocytes of RA patients compared to healthy individuals
Timeframe: within 3 days of samples collection
Salma Khalaf Abdelmageed, Assistant Lecturer