Active — Not RecruitingPhase 1

Clinical and Laboratory Evaluation of Resveratrol Loaded Nanoparticles in the Treatment of Periodontitis: A Randomized Controlled Clinical Trial

Egypt48 participantsStarted 2025-08-09

Plain-language summary

The Aim of this study is to test the effectiveness of locally applied resveratrol as an adjunct to scaling and root planing in the treatment of periodontitis (primary outcome) . Also to assess the level of COX-2 and superoxide dismutase (SOD) in the gingival crevicular fluid samples using the commercially available kits.

Who can participate

Age range25 Years – 55 Years

SexALL

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Inclusion criteria

✓. Adult patient 25-55 years.
✓. Presence of ≥20 teeth.
✓. PPD \>3\&≤5 mm.
✓. The patients are in good systemic health.
✓. Patients have not received any periodontal surgery in the areas that will be assessed in the last 6 months

Exclusion criteria

✕. Patients with systemic diseases.
✕. Pregnant and lactating women.
✕. Heavy Smokers and tobacco chewers.
✕. Patients do not follow oral hygiene measures.
✕. Patients with a known or suspected allergy to any material used in the study.

What they're measuring

Clinical attachment level (CAL) as Clinical periodontal parameter

Timeframe: 3 months

Trial details

NCT IDNCT07397026

SponsorHagar Ahmed Ali Mohammed Elzain

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-01

View on ClinicalTrials.gov More Periodontitis Stage III trials