Not Yet RecruitingNot Applicable

SCUBE Proteins in Polycystic Ovary Syndrome (IPSOS)

Italy56 participantsStarted 2026-01-15

Plain-language summary

This study investigates circulating levels of SCUBE-1 and SCUBE-3 proteins in women with polycystic ovary syndrome (PCOS) compared with healthy controls. Differences between normoinsulinemic and hyperinsulinemic PCOS subgroups will be evaluated, as well as correlations with clinical and metabolic parameters related to inflammation and cardiovascular risk.

Who can participate

Age range18 Years – 35 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Female subjects aged 18-35 years * Diagnosis of polycystic ovary syndrome (normoinsulinemic or hyperinsulinemic) * Availability of basal hormonal evaluation and oral glucose tolerance test * Healthy women for control group * Written informed consent Exclusion Criteria: * Pregnancy * History of cardiovascular disease * Diabetes mellitus or impaired glucose tolerance * Hypertension * Significant hepatic or renal disease * Other endocrine disorders * Neoplastic diseases * Psychiatric disorders * Autoimmune diseases * Shift work * Obesity * Refusal to sign informed consent

What they're measuring

Circulating SCUBE-1 levels

Timeframe: At enrollment

Trial details

NCT IDNCT07396402

SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-01

Contact for this trial

Rosanna Apa, MD, PhD

+390630155872 rosanna.apa@policlinicogemelli.it

View on ClinicalTrials.gov More Polycystic Ovary Syndrome (PCOS) trials