CompletedNot Applicable

Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomy

Pakistan136 participantsStarted 2022-01-10

Plain-language summary

This randomized controlled trial aims to evaluate the efficacy of intraoperative methylene blue (MB) spray in improving the identification and preservation of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs) during thyroidectomy. The study compares outcomes between patients receiving topical MB spray and those undergoing conventional visual dissection alone. Primary outcomes include the incidence of RLN injury and postoperative serum calcium levels.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion Criteria: * benign multinodular goiter scheduled for thyroidectomy. Exclusion Criteria: * Recurrent/metastatic disease * Preoperative vocal cord dysfunction * Coagulopathy * Methylene blue allergy * Hepatic/renal impairment

What they're measuring

Incidence of recurrent laryngeal nerve injury

Timeframe: 2 hours (at extubation)

Postoperative serum calcium levels

Timeframe: At 72 hours

Trial details

NCT IDNCT07395388

SponsorServices Hospital, Lahore

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2025-12-31

View on ClinicalTrials.gov More Benign Multinodular Goiter trials