Active — Not RecruitingNot Applicable

Longitudinal Oral Health Changes After Head and Neck Radiotherapy

Egypt100 participantsStarted 2025-02-01

Plain-language summary

This prospective observational study evaluates how head and neck radiotherapy affects oral health over time. Patients with head and neck cancer undergoing standard radiotherapy are followed from before treatment through multiple post-treatment visits. Changes in periodontal health, dental status, salivary function, and patient-reported oral health quality of life are assessed. The study aims to better understand the long-term oral complications of radiotherapy and to support improved preventive and supportive dental care for cancer patients.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 years * Histologically confirmed head and neck malignancy * Planned radiotherapy dose ≥50 Gy * Presence of at least 20 natural teeth * No periodontal treatment during the preceding 6 months * Ability to comply with the scheduled follow-up visits Exclusion Criteria: * Previous head and neck radiotherapy * Autoimmune salivary gland disorders * Current bisphosphonate or anti-resorptive therapy * Pregnancy * Uncontrolled systemic disease (HbA1c \>9% for diabetic patients) * Severe periodontal destruction requiring immediate surgical intervention

What they're measuring

Change in Clinical Attachment Level (CAL)

Timeframe: Baseline, end of radiotherapy, and 3, 6, 9, and 12 months post-radiotherapy

Trial details

NCT IDNCT07394842

SponsorAin Shams University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-02-01

View on ClinicalTrials.gov More Head & Neck Cancer trials