The objective of this observational study is to examine the impact of gender-affirming hormone therapy (GAHT) on mood in transgender individuals and to explore its potential association with early atherosclerotic processes. The main questions it aims to answer are: * Whether GAHT in transgender individuals has a psychological and functional impact, assessed through mood, stress, and self-esteem. Additionally, the study will analyze whether morphofunctional changes (including body composition, muscle strength, cardiorespiratory fitness, and metabolic flexibility) are related to inflammatory responses and psychological well-being. * Whether the administration of GAHT poses a cardiovascular risk by influencing biochemical, inflammatory, and oxidative markers, mitochondrial function, and the activation of the NLRP3 inflammasome in leukocytes. Participants will undergo evaluation of early stages of the atherosclerotic process through the analysis of leukocyte-endothelial interactions, adhesion molecule expression, and ankle-brachial index (ABI), as well as periodontal parameters. Overall, this study aims to contribute to improving healthcare delivery and promoting more equitable and gender-affirming medical services tailored to the needs of transgender individuals.
Age range
16 Years
Sex
ALL
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Changes in the degree of activation of the inflammasome complex in transgender individuals following gender-affirming hormone therapy.
Timeframe: At recruitment
Changes in endothelial function in the study population.
Timeframe: At recruitment
Changes in endothelial function at molecular level in the study population.
Timeframe: At recruitment
Changes in the systemic inflammation status in the study population.
Timeframe: At recruitment
Changes in the expression of genes related to inflammatory pathways in PBMC in the study population.
Timeframe: At recruitment
Changes in the expression of genes related to oxidative stress levels in PBMC in the study population.
Timeframe: At recruitment
Changes in the expression of genes related to cellular respiration in PBMC in the study population.
Timeframe: At recruitment
Changes in the degree of activation of the inflammasome complex in transgender individuals following gender-affirming hormone therapy.
Timeframe: At recruitment