Not Yet RecruitingNot Applicable

Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone

50 participantsStarted 2026-02-01

Plain-language summary

The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal anesthesia.

Who can participate

Age range65 Years

SexALL

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Inclusion Criteria: * Patients of both genders ageing 65 years or above. * ASA grade I to III. * Undergo elective lower limb surgery under spinal anesthesia * Agree to collect one's own CSF and blood samples Exclusion Criteria: * Past history of depression,anxiety,delirium and schizophrenia . * Past history of drug dependence. * Past history of dementia,including Alzheimer disease(AD). * Preoperative Montreal Cognitive Assessment (MoCA) score \<26. * Inability to understand or cooperate with the evaluation scale or questionnaire. * Refuse collecting one's own CSF and blood samples.

What they're measuring

To investigate the impact of preoperative sleep problems as indicators of delayed neurocognitive recovery (DNR) in elderly adults following spinal anesthesia.

Timeframe: Baseline, one week, three months

Trial details

NCT IDNCT07392840

SponsorMinia University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-02-01

Contact for this trial

Mohamed Yasein Mohamed, Assistant lecturer

+20 01016383701 myasein76@yahoo.com

View on ClinicalTrials.gov More Postoperative Cognitive Dysfunction trials