OptimAIR: Towards Right Care in Asthma Through Point-of-care Phenotyping, Guideline-based Assessm… (NCT07390669) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
OptimAIR: Towards Right Care in Asthma Through Point-of-care Phenotyping, Guideline-based Assessment and Management Optimalisation Using the AsthmaOptimiser in Primary Care
Asthma is mainly managed in primary care, yet disease control remains suboptimal. Many patients experience ongoing symptoms, exacerbations, and frequent short-acting β₂-agonist use, while underestimating the severity of their condition. Approximately 40% of patients have uncontrolled asthma based on Asthma Control Questionnaire scores. This highlights the need for structured assessment of asthma control, risk factors, inhaler technique, and alignment of treatment with international guidelines.
Structured asthma reviews and digital support tools may help optimize and personalize asthma management, particularly for patients at increased risk of exacerbations. Novel risk prediction tools using biomarkers such as FeNO and blood eosinophils show promise but are not yet routinely used in primary care.
This study aims to assess asthma control, identify patients at higher risk of exacerbations, and explore opportunities for management optimization in primary care. In addition, it supports the development of a longitudinal respiratory registry to facilitate clinical research and participation in future clinical trials.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 18 years or older
* Documented physician diagnosis of asthma
* Treated with ICS+LABA
* 1 or more exacerbation(s) requiring oral or systemic corticosteroids for at least 3 days or hospital admission, or emergency room visit within 12 months prior to the OptimAIR study visit
Exclusion Criteria:
* Well controlled asthma, defined as ACQ-6 score ≤ 0.75 and normal oscillometry (ALDS result: "normal lung function")
* Not able to understand the patient information sheet and informed consent form
* Other significant respiratory disease than asthma
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses something called point-of-care phenotyping and an AsthmaOptimiser tool — can you explain what that actually involves during a visit, and whether that kind of assessment would give us useful information about my asthma that we don't already have?
2Since this trial is 'active not recruiting,' am I too late to join, and is there a similar program or tool already available in your practice that does GINA-guided asthma management reviews?
3The trial is focused on finding opportunities to optimise treatment using GINA guidelines — does that mean my current treatment plan has already been reviewed against those same guidelines, and are there any gaps we should address regardless of this trial?
4This study is listed as Phase NA, which typically means it's more about evaluating a care process than testing a new drug — does that change how you'd think about the potential benefits or risks compared to a standard medication trial?
5If the AsthmaOptimiser identifies that my asthma is a specific type or phenotype, would that actually change the treatment options you'd recommend for me, and are those options already available outside of a trial setting?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number and distribution of identified opportunities for treatment and management optimisation (GINA-guided)
Timeframe: During the study visit (baseline; single visit)