The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion (NCT07390032) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion
China230 participantsStarted 2026-03-01
Plain-language summary
This study assesses the efficacy and safety of endovascular treatment for acute mild basilar artery occlusion within a multicenter, prospective, open-label, endpoint-blinded, randomized controlled clinical trial.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Age≥18
✓. Acute ischemic stroke in posterior circulation, the time from stroke onset (or finally found normal) to randomization was within 24 hours
✓. Acute basilar artery occlusion confirmed by CTA,MRA,or DSA
✓. NIHSS score≥2 points and\<10 points from the onset of the disease to before randomization
✓. Posterior circulation large core infarction:NCCT or DWI showed pc-ASPECTS≥6, or Pons-Midbrain Index (PMI)\<3
✓. No significant functional disability before stroke (mRS≤2 points)
✓. Each patient or their legal representative must provide written informed consent before enrolment
Exclusion criteria
✕. Any sign of intracranial hemorrhage (except microbleeds) on brain imaging prior to randomization
✕. Complete cerebellar infarct with significant mass effect, or bilateral thalamic infarction as evidenced by baseline neuroimaging
✕. Known or highly suspected chronic occlusion of basilar artery
✕. History of contraindication for contrast medium (except mild rash)
✕. CTA/MRA/DSA confirmed occlusion of anterior and posterior circulation
✕
What they're measuring
1
The rate modified Rankin Scale (mRS) score 0-2 at 90 days
. Severe stenosis, arterial dissection, or excessive tortuosity of the extracranial or intracranial segments of the vertebral artery may result in the inability of interventional instruments to be successfully delivered or positioned
✕. Current pregnant or breast-feeding
✕. Refractory hypertension (defined as systolic blood pressure\>185 mmHg or diastolic blood pressure\>110 mmHg) that cannot be controlled by drug treatment