Not Yet RecruitingNot Applicable

Efficacy of Acupuncture-Mesalazine Combination Therapy in Ulcerative Colitis.

China80 participantsStarted 2026-02-01

Plain-language summary

This study aims to evaluate the efficacy and safety of acupuncture combined with mesalazine (an integrated acupuncture-medication regimen) for ulcerative colitis.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion criteria

✓. documented diagnosis of UC；
✓. age 18-65 years, regardless of gender;
✓. mildly to moderately active UC, defined as a baseline total Mayo score between 3 and 10；
✓. willing to receive the complete protocol of intradermal thumbtack needle embedding therapy (12 sessions across three treatment courses)；
✓. Willing to undergo two colonoscopies (pre-treatment and post-treatment)；
✓. complete all baseline assessments;
✓. capable of understanding and voluntarily sign the informed consent form.

Exclusion criteria

✕. diagnosed with or suspected to have other type of inflammatory bowel disease, such as Crohn's disease;
✕. patients in clinical remission or with severe disease activity ( baseline total Mayo score \< 3, or \> 10 );
✕. having severe gastrointestinal complications or a recent surgical history, including but not limited to: short bowel syndrome, toxic megacolon, intestinal perforation, complete intestinal obstruction, active massive gastrointestinal hemorrhage, or having undergone major abdominal or intestinal surgery within the past 6 months.
✕. patients unwilling to undergo colonoscopy;
✕. significant or unstable comorbidities (e.g., cardiovascular, respiratory, hepatic, or renal diseases);
✕. patients with malignant tumors (including but not limited to colorectal cancer);
✕. patients with a history of intradermal thumbtack needle embedding;
✕. pregnant or lactating women;

What they're measuring

Clinical remission rate

Timeframe: Week 13-16 after randomization

Trial details

NCT IDNCT07389824

SponsorQin Yu

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-09-30

Contact for this trial

Zhou Pu

02783663625 tongjihlunli@163.com

View on ClinicalTrials.gov More Ulcerative Colitis trials