By InvitationNot Applicable

INVESTIGATION OF THE EFFECT OF DIFFERENT ACTIVATION TECHNIQUES ON TLR9, IL6, IL10, TNF-ALFA LEVELS IN HEALTHY AND TYPE 2 DIABETIC PATIENTS WITH APICAL PERIODONTITIS REQUIRING RETREATMENT

Turkey (Türkiye)90 participantsStarted 2026-01-28

Plain-language summary

The subject of this thesis study is the effects of SWEEPS laser and ultrasonic activation methods on the immune response in the treatment of apical periodontitis in healthy individuals and patients with Type 2 diabetes requiring retreatment, based on a comparative investigation of Toll-like Receptor 9 (TLR-9), Interleukin-6 (IL-6) and Tumour Necrosis Factor alpha (TNF-α), and Interleukin-10 (IL-10) levels.

Who can participate

Age range18 Years – 50 Years

SexALL

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Inclusion criteria

✓. Patients aged 18-50 years
✓. Patients with ASA I status
✓. Patients with Type 2 diabetes whose HbA1c values are between 5.5% and 9.0%, with diabetes diagnosis confirmed by medical history and laboratory tests (HbA1c test)
✓. Upper and lower incisors and lower premolars with chronic apical periodontitis,
✓. Teeth requiring retreatment with a PAI score ≥3 will be included in the study. (15)

Exclusion criteria

✕. ASA II or higher,
✕. Pregnant women or those suspected of being pregnant,
✕. Patients with localized or generalized periodontitis,
✕. Patients with inflammatory or autoimmune diseases such as hepatitis, HIV infection, immunosuppressive chemotherapy, bleeding disorders, Behçet's syndrome, and arthritis,
✕. Individuals with HbA1c levels above 9%,

What they're measuring

TLR9 expression levels in periapical exudate and gingival crevicular fluid samples

Timeframe: Immediately after the procedure

Trial details

NCT IDNCT07389772

Sponsorbengisu yüksel

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06-30

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